As a dietary supplement, I3C provides key nutritional support for liver detoxification. It also plays an important role in supporting female reproductive health. The majority of ingested I3C is absorbed in the small intestine as diindolylmethane (DIM), which is thought to be the primary contributor to I3C's beneficial properties. DIM has been shown to selectively bind to estrogen receptors and may act as an estrogen antagonist at physiological concentration.
In the liver, I3C promotes the metabolism of estrogen and increases the ratio of 2-hydroxy estrogen to 16-hydroxy estrogen. The 2-hydroxy estrogens, less active than the 16-hydroxy estrogens, generally are eliminated more rapidly from the body. One prospective study found postmenopausal women with the most favorable urinary 2:16-hydroxyestrone ratio were most likely to maintain good female health.
Preliminary studies have examined the efficacy, safety, and optimal supplementation of I3C. A 12-week phase I trial conducted on 17 women found a 66-percent increase in urinary 2:16-hydroxyestrone ratio with administration of 400 mg I3C daily.
maintains optimal 2-hydroxy/16-hydroxy estrogen ratios
found in cabbage family vegetables, it's a source of DIM
nutritional support for liver detoxification
made without flowing agents that can inhibit bioavailability
These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose, treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.
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